Metaphore: Antibody Discovery and Molecular Biology Co-Op

<div class="p-pdf_viewer_thumbnail"> <div data-page-number="1"> <p><strong>This position is open exclusively to current Northeastern University Co-Op students.<br><br>Work Period: </strong>January 2027 to June 2027. This is a full - time, 40 hours per week position with 5 days in office.</p> <p><strong>About Metaphore Biotechnologies</strong></p> <p>Metaphore Biotechnologies, Inc. is a privately held biotechnology company building the next generation of biological therapeutics. Inspired by nature, our mission is to transform patient lives by unlocking the power of biological therapeutics with a new mimic-discovery platform.</p> <p><strong>About Flagship Pioneering</strong></p> <p>Metaphore Biotechnologies, Inc. was founded by <strong>Flagship Pioneering's </strong>venture creation engine that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the company’s Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at <a href="https://www.flagshippioneering.com/"><span class="s1">www.flagshippioneering.com</span></a>.</p> <p class="p1"><strong>Flagship Pioneering Co-Op Program</strong></p> <p class="p1">Welcome to<strong> </strong>Flagship Pioneering Co-Op Program for the cohort dreaming big and taking courageous leaps. You'll join fellow peers across our ecosystem of companies and learning firsthand how we build first-in-category companies. You’ll have access to <strong>enrichment sessions</strong>, a <strong>dedicated professional development track</strong>, and a <strong>mentor</strong> that help guide you toward your next step. By the end, you will carry on a <strong>meaningful project outcome</strong>, a <strong>genuine network</strong>, and <strong>a front-row view of how Flagship pioneer</strong> new ventures that change the world.<br><br><strong>About the Role<br></strong><br><span class="s4">We are seeking a highly motivated Co-op to support early-stage discovery efforts within our Peripheral Artery Disease (PAD) program, a newly initiated therapeutic discovery program focused on achieving proof-of-concept (POC) by the end of the year. This position will provide hands-on experimental support for routine but mission-critical discovery</span><span class="s4"><span class="Apple-converted-space"> </span>and molecular biology</span><span class="s4">activities that enable efficient advancement of the program. The role offers meaningful exposure to foundational discovery workflows within a fast-paced, research-focused environment, with opportunities to contribute across additional programs as bandwidth allows.<span class="Apple-converted-space"> </span></span><span class="s4">This position is a unique joint effort between the Discovery and Molecular Biology teams, with opportunities to support cloning projects focused on antibody expression, contribute to high-throughput cloning pipelines, and gain exposure to laboratory automation.</span></p> <p><strong>Key Responsibilities:</strong></p> <p><span class="s4">The Co-op’s core responsibilities will focus on executing routine, mission-critical discovery<span class="Apple-converted-space"> </span></span><span class="s4">and molecular biology<span class="Apple-converted-space"> </span></span><span class="s4">experiments that support target validation, hit identification, and early characterization within the PAD program. The role will involve hands-on laboratory work using established protocols, with opportunities to contribute to:</span></p> <ul> <li>Molecular biology techniques supporting library preparation, cloning, and hit screening</li> <li><span class="s4">Antibody selection methodologies, including phage display–based biopanning on PAD-relevant targets</span></li> <li>ELISA-based screening and other binding and characterization assays</li> <li> <div class="s8"><span class="s4">Cloning projects supporting antibody expression and high-throughput cloning pipelines</span></div> </li> <li> <div class="s8"><span class="s4">Laboratory automation workflows, as applicable</span></div> </li> <li> <div class="s8"><span class="s4">Additional foundational assays required to advance early discovery milestones efficiently</span><span class="s4"> </span></div> </li> </ul> <p><span class="s4">The Co-op will work closely with<span class="Apple-converted-space"> </span>Discovery and Molecular Biology<span class="Apple-converted-space"> </span>scientists to generate high-quality experimental data that supports<span class="Apple-converted-space"> </span>timely<span class="Apple-converted-space"> </span>decision-making and<span class="Apple-converted-space"> </span>progress toward POC.<span class="Apple-converted-space"> </span>As a shared resource across these teams, the role may also contribute to assay execution, cloning, and general laboratory needs for additional discovery programs as capacity allows.</span></p> <p><strong>Required Qualifications:</strong></p> <ul> <li> <div class="s9"><span class="s4">A collaborative and adaptable mindset with a positive attitude and a strong willingness to learn new skills</span></div> </li> <li> <div class="s9"><span class="s4">Basic molecular biology and protein biochemistry skills</span></div> </li> <li> <div class="s9"><span class="s4">Familiarity with standard wet-lab techniques</span></div> </li> <li> <div class="s9"><span class="s4">Ability to follow established protocols accurately and reproducibly</span></div> </li> <li> <div class="s9"><span class="s4">Strong organizational skills and attention to detail</span></div> </li> <li> <div class="s9"><span class="s4">Willingness to work across multiple projects and teams in a dynamic environment</span></div> </li> <li> <div class="s9"><span class="s4">Comfort contributing in a fast-paced, resource-conscious discovery setting</span></div> </li> </ul> <p><strong>Preferred Qualifications:</strong></p> <p><em>Note: These qualifications are not required. Candidates who are eager to learn and confident in their ability to acquire these skills with proper training are encouraged to apply.</em></p> <ul> <li> <div class="s11"><span class="s4">Prior laboratory experience in an academic or industry setting</span></div> </li> <li> <div class="s11"><span class="s4">Hands-on experience with phage display, ELISAs, or related assay formats (e.g. yeast or mammalian display)</span></div> </li> <li> <div class="s11"><span class="s4">Experience with cloning and routine molecular biology techniques such as Gibson or Golden Gate Assembly</span></div> </li> <li> <div class="s11"><span class="s4">Basic understanding of protein or antibody biochemistry</span></div> </li> <li> <div class="s11"><span class="s4">Experience maintaining clear and accurate experimental records</span></div> </li> </ul> </div> </div> <p><strong>What We Offer</strong></p> <ul> <li><strong>Build alongside founders. </strong>You’ll work inside the same hypothesis-driven process Flagship uses to conceive and launch first-in-category companies.</li> <li><strong>This can be the start of a longer story. </strong>Strong co-ops are considered for future opportunities across Flagship and its portfolio companies, not just for this one role.</li> <li><strong>Work alongside people who left the safe path</strong>. Your colleagues are scientists, engineers, and operators who chose to build something new rather than join something already established.</li> <li><strong>Take on real ownership. </strong>You're contributing to ventures that are still being defined. Your work can shape real decisions, not just support them.</li> <li><strong>Be paid like the contributor you are. </strong>Compensation reflects the real work you take on.</li> </ul> <p>Flagship Pioneering is committed to <strong>equal employment opportunity </strong>regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.</p> <p>The pay range for this role is $25 - $35 per hour. This role is a short-term engagement that is not eligible for health and welfare benefits. Retirement benefits may be available after completing a set number of hours. Compensation and benefits information is based on Metaphore Biotechnologies, Inc.'s good faith estimate as of the date of publication and may be modified in the future.</p> <div class="content-conclusion"> </div> <div class="content-conclusion"> <p><strong>Privacy Notice for Applicants: </strong>When you apply for a role at Flagship Pioneering, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.</p> </div> <p id="pay-transparency" style="margin: 0 !important; padding: 0 !important; float: none !important; clear: both !important; display: block;">The pay range for this role is $25 - $35 per hour. This role is a short-term engagement that is not eligible for health and welfare benefits. Retirement benefits may be available after completing a set number of hours. Compensation and benefits information is based on Metaphore Biotechnologies, Inc.'s good faith estimate as of the date of publication and may be modified in the future.</p><div class="content-conclusion"><p><strong>Privacy Notice for Applicants: </strong>When you apply for a role at Flagship Pioneering, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.</p></div>